反应详情

Stir 29.9 g of 2,2-diethoxy-1-methylpyrrolidine and 28 g of 4-nitrophenylacetonitrile in 80 ml of benzene for one hour at room temperature. Distil off the solvent from the resulting reaction mixture under a vacuum to produce a crystalline residue. Recrystallize this residue from ethanol/diethyl ether. Concentrate the mother liquor to obtain a total of 29.5 g (70% of theory) of the title compound as dark-brown shiny crystals of m.p. 67°.

1. customDistil off the solvent
2. customfrom the resulting reaction mixture under a vacuum
3. customto produce a crystalline residue
4. customRecrystallize this residue from ethanol/diethyl ether
5. concentrationConcentrate the mother liquor