p-Nitrophenylacetonitrile → 2-(alpha-Cyano-4-nitrobenzylidene)-1-methylpyrrolidine

Participants

Reaction Steps

Stir 29.9 g of 2,2-diethoxy-1-methylpyrrolidine and 28 g of 4-nitrophenylacetonitrile in 80 ml of benzene for one hour at room temperature. Distil off the solvent from the resulting reaction mixture under a vacuum to produce a crystalline residue. Recrystallize this residue from ethanol/diethyl ether. Concentrate the mother liquor to obtain a total of 29.5 g (70% of theory) of the title compound as dark-brown shiny crystals of m.p. 67°.

Provenance & Evidence