Water → HCID 23452555, compound

HRID 1278079Notes

Reaction equation

HRID 1278079 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][CH:7]2[CH2:11][CH2:10][CH2:9][N:8]2[CH2:12][CH2:13][CH2:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[CH:4][CH:3]=1.[BH4-].[Na+].O>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:11][CH2:10][CH2:9][N:8]2[CH2:12][CH2:13][CH2:14][CH:15]([C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)[OH:23])=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 23452544HCID 23452544, compound

Product 1

HCID 23452555HCID 23452555, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Stir 0.8 g of 2-(4-chlorobenzyl)-1-[3-(4-fluorobenzoyl)propyl]pyrrolidine at room temperature for 3 hours with 0.5 g of sodium borohydride in 8 ml of methanol/2 ml of water. Concentrate the resulting reaction mixture and then take up the concentrate with water/diethyl ether. Dry the ethereal phase over sodium sulfate and distil off the solvent to obtain the title compound as light-brown viscous oil.

Workup

  1. concentrationConcentrate
  2. customthe resulting reaction mixture
  3. concentrationconcentrate with water/diethyl ether
  4. dry with materialDry the ethereal phase over sodium sulfate
  5. customdistil off the solvent

Sources & evidence

ORD record
ord-b12d7fe5f5064e2a9c7676ffe2f909f5
Source dataset
uspto-grants-1981_07
Patent number
US04279918

Reaction notes

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