4-methoxy-N,6-dimethylpyrimidin-2-amine → N-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]-2-thiophene sulfonamide

HRID 127813Notes

Reaction equation

HRID 127813 reaction equation
[CH3:1][NH:2][C:3]1[N:8]=[C:7]([O:9][CH3:10])[CH:6]=[C:5]([CH3:11])[N:4]=1.[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[S:17]([N:20]=[C:21]=[O:22])(=[O:19])=[O:18]>C(#N)C>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([CH3:11])[N:4]=[C:3]([N:2]([CH3:1])[C:21]([NH:20][S:17]([C:13]2[S:12][CH:16]=[CH:15][CH:14]=2)(=[O:18])=[O:19])=[O:22])[N:8]=1

Participants

4

Reactant 2

HCID 13766724-methoxy-N,6-dimethylpyrimidin-2-amineHCID 12875192Thiophene-2-sulfonyl isocyanate

Product 1

HCID 12875193N-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]-2-thiophene sulfonamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a mixture, 1.5 g of 2-methylamino-4-methoxy-6-methylpyrimidine in 50 ml of acetonitrile is added 1.9 g of 2-thiophenesulfonyl isocyanate. Filtration affords N-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]-2-thiophene sulfonamide.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-b6bcd6aa682b4c28a887cd97aef491e6
Source dataset
uspto-grants-1981_03
Patent number
US04257802

Reaction notes

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