Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 127813Generated: October 28, 2026

4-methoxy-N,6-dimethylpyrimidin-2-amine → N-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]-2-thiophene sulfonamide

https://huagongshe.com/reaction/127813

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-methoxy-N,6-dimethylpyrimidin-2-amineHCID 1376672—
ReactantThiophene-2-sulfonyl isocyanateHCID 12875192—
SolventAcetonitrileHCID 6342—
ProductN-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]-2-thiophene sulfonamideHCID 12875193—

Reaction Steps

To a mixture, 1.5 g of 2-methylamino-4-methoxy-6-methylpyrimidine in 50 ml of acetonitrile is added 1.9 g of 2-thiophenesulfonyl isocyanate. Filtration affords N-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]-2-thiophene sulfonamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04257802
Source datasetuspto-grants-1981_03
ORD IDord-b6bcd6aa682b4c28a887cd97aef491e6
Source noteuspto-grants-1981_03