HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-isopropoxy-3-(trifluoromethyl)aniline(SALTDATA: HCl)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 3-(Trifluoromethyl)-4-isopropoxynitrobenzene | HCID 10538559 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-isopropoxy-3-(trifluoromethyl)aniline(SALTDATA: HCl) | HCID 12876625 | — |
Reaction Steps
137.5 g of iron filings were added in portions to a refluxing mixture of 113.3 g of 2A, 1200 ml of 5% aqueous acetic acid and 50 ml of methanol. The resulting mixture was refluxed for one hour and filtered while hot. Work-up by either extraction of the cooled filtrate gave 4-isopropoxy-3-(trifluoromethyl)aniline (2B), as an amber oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04257805 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-d8fc7d95c6514e20833bbfd97c4524de |
| Source note | uspto-grants-1981_03 |