反应详情

137.5 g of iron filings were added in portions to a refluxing mixture of 113.3 g of 2A, 1200 ml of 5% aqueous acetic acid and 50 ml of methanol. The resulting mixture was refluxed for one hour and filtered while hot. Work-up by either extraction of the cooled filtrate gave 4-isopropoxy-3-(trifluoromethyl)aniline (2B), as an amber oil.

1. temperatureThe resulting mixture was refluxed for one hour
2. filtrationfiltered while hot
3. extractionWork-up by either extraction of the cooled filtrate