2-Amino-5-chloropyridine → N-[(5-Chloropyridin-2-yl)carbamoyl]-2,6-difluorobenzamide

HRID 1278182Notes

Reaction equation

HRID 1278182 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[F:9][C:10]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:11]=1[C:12]([N:14]=[C:15]=[O:16])=[O:13]>>[F:9][C:10]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:11]=1[C:12]([NH:14][C:15]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)=[O:16])=[O:13]

Participants

3

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 27333692,6-Difluorobenzoyl isocyanate

Product 1

HCID 326523N-[(5-Chloropyridin-2-yl)carbamoyl]-2,6-difluorobenzamide

Procedure

An 0.5 g. portion of 5-chloro-2-aminopyridine was reacted with 0.6 g. of 2,6-difluorobenzoyl isocyanate as described in Example 1. The isolated product was 0.8 g. of the product named in the heading above, m.p. 226°-229° C. Its elemental analysis showed the following results:

Workup

  1. customfollowing results

Sources & evidence

ORD record
ord-1a5a4bbc15834425aeb9a7cbd6c21548
Source dataset
uspto-grants-1981_07
Patent number
US04281003

Reaction notes

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