2-Chloro-6-fluorobenzamide → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

HRID 1278185Notes

Reaction equation

HRID 1278185 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH2:6])=[O:5].[Br:12][C:13]1[CH:14]=[CH:15][C:16]([NH:19][C:20](OC2C=CC=CC=2)=[O:21])=[N:17][CH:18]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH:6][C:20]([NH:19][C:16]1[CH:15]=[CH:14][C:13]([Br:12])=[CH:18][N:17]=1)=[O:21])=[O:5]

Participants

3

Reactant 2

HCID 985642-Chloro-6-fluorobenzamideHCID 63235910Phenyl (5-bromopyridin-2-yl)carbamate

Product 1

HCID 130230741-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

Procedure

A portion of 2-chloro-6-fluorobenzamide is dissolved in an organic solvent, and 5-bromo-2-pyridinylaminocarboxylic acid, phenyl ester is added. The reaction mixture is stirred with heating for a period of time, and is then evaporated under vacuum. The product, identical to the product of Example 2 above, is isolated from the residue by recrystallization.

Workup

  1. additionis added
  2. temperaturewith heating for a period of time
  3. customis then evaporated under vacuum

Sources & evidence

ORD record
ord-46b19ca476ac4feb8cf12d4b47fcf43c
Source dataset
uspto-grants-1981_07
Patent number
US04281003

Reaction notes

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