2-Amino-5-(trifluoromethyl)pyridine → 1-(2,6-Difluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

HRID 1278186Notes

Reaction equation

HRID 1278186 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[F:12][C:13]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:14]=1[C:15]([NH:17][C:18](OC1C=CC([N+]([O-])=O)=CC=1)=[O:19])=[O:16]>>[F:12][C:13]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:14]=1[C:15]([NH:17][C:18]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:8][N:7]=1)=[O:19])=[O:16]

Participants

3

Reactant 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 572860812,6-Difluorobenzamidocarboxylic acid, 4-nitrophenyl ester

Product 1

HCID 128006031-(2,6-Difluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

Procedure

A portion of 5-trifluoromethyl-2-aminopyridine is dissolved in an inert organic solvent, and to the solution is added a portion of 2,6-difluorobenzamidocarboxylic acid, 4-nitrophenyl ester. The reaction mixture is stirred at elevated temperature for a period of time, after which the reaction mixture is evaporated to dryness under vacuum, and the product named in the heading above, identical to the product of Example 1, is isolated by recrystallization.

Workup

  1. customafter which the reaction mixture is evaporated to dryness under vacuum
  2. customis isolated by recrystallization

Sources & evidence

ORD record
ord-b3145ff5191d4589bee3f52e36913bba
Source dataset
uspto-grants-1981_07
Patent number
US04281003

Reaction notes

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