Acetic Acid → 2044722-64-5

HRID 1278204Notes

Reaction equation

HRID 1278204 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14]C(C#N)=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[ClH:18].[C:19]([OH:22])(=[O:21])[CH3:20]>>[ClH:18].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:20]([C:19]([OH:22])=[O:21])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 112183037-(3-Pyridyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Product 1

HCID 705726672044722-64-5

Procedure

A mixture of 0.10 mole of 7-(3-pyridyl)pyrazolo-[1,5-a]pyrimidine-3-carbonitrile and concentrated hydrochloric acid in acetic acid is heated at reflux temperature for 16 hours. The solvent is removed to give 7-(3-pyridyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylate hydrochloride. The preceding compound is added portionwise to a chilled solution of 0.30 mole of diborane in tetrahydrofuran. After the addition the mixture is stirred for 16 hours and poured onto ice to give the product of the example.

Workup

  1. temperatureis heated
  2. temperatureat reflux temperature for 16 hours
  3. customThe solvent is removed

Sources & evidence

ORD record
ord-11c79a82301247bdadac3f4a3b140bbe
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

Loading…