反应详情

温度

10 °C

A mixture of 42.2 g of 5A and 50 g of concentrated sulfuric acid in 600 ml of water was refluxed for 7 hours. The resulting mixture was charcoaled, filtered, cooled to 10° C. and made alkaline with sodium hydroxide. The resulting mixture was extracted with ether. The extract was dried and the ether evaporated to give 3-chloro-4-fluoro-N-methyl-aniline, (5B), as a yellow oil.

1. temperaturewas refluxed for 7 hours
2. filtrationfiltered
3. extractionThe resulting mixture was extracted with ether
4. customThe extract was dried
5. customthe ether evaporated