HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 127822Generated: October 30, 2026
Sulfuric Acid → 3-Chloro-4-fluoro-N-methylaniline
https://huagongshe.com/reaction/127822
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | N-(3-chloro-4-fluorophenyl)N-methylformamide | HCID 12876631 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Chloro-4-fluoro-N-methylaniline | HCID 12876632 | — |
Reaction Steps
A mixture of 42.2 g of 5A and 50 g of concentrated sulfuric acid in 600 ml of water was refluxed for 7 hours. The resulting mixture was charcoaled, filtered, cooled to 10° C. and made alkaline with sodium hydroxide. The resulting mixture was extracted with ether. The extract was dried and the ether evaporated to give 3-chloro-4-fluoro-N-methyl-aniline, (5B), as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04257805 |
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| Source dataset | uspto-grants-1981_03 |
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| ORD ID | ord-a95517720cb2420d9d6caa979bbb692f |
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| Source note | uspto-grants-1981_03 |
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