2-Propen-1-one, 3-(dimethylamino)-1-(4-pyridinyl)- → HCID 12766263, compound

HRID 1278245Notes

Reaction equation

HRID 1278245 reaction equation
C[N:2]([CH3:13])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=O.N[C:15]1[C:19]([C:20]#[N:21])=C[NH:17][N:16]=1>C(O)(=O)C>[N:10]1[CH:9]=[CH:8][C:7]([C:5]2[N:17]3[N:16]=[CH:15][C:19]([C:20]#[N:21])=[C:13]3[N:2]=[CH:3][CH:4]=2)=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 7145312-Propen-1-one, 3-(dimethylamino)-1-(4-pyridinyl)-HCID 178510443HCID 178510443, compound

Product 1

HCID 12766263HCID 12766263, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 1.12 g. of 3-dimethylamino-1-(4-pyridyl)-2-propen-1-one and 0.69 g. of 3-aminopyrazole-4-carbonitrile in 25 ml. of glacial acetic acid is refluxed 6 hours. The solvent is removed under reduced pressure and the product worked up as for Example 53 to give 0.60 g. of crystals, m.p. 137°-138° C.

Workup

  1. additionA mixture of 1.12 g
  2. customThe solvent is removed under reduced pressure
  3. customto give 0.60 g

Sources & evidence

ORD record
ord-2dadd8ee0f3a481fafc9b6286402374f
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

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