1-Chlorobenzotriazole → 3-Chloro-7-(4-pyridyl)pyrazolo[1,5-a]pyrimidine

HRID 1278247Notes

Reaction equation

HRID 1278247 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:12]3[N:13]=[CH:14][CH:15]=[C:11]3[N:10]=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[Cl:16]N1C2C=CC=CC=2N=N1>ClCCl>[Cl:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:4]3[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=3)=[CH:8][CH:9]=[N:10][C:11]=12

Participants

4

Reactant 2

HCID 887611-ChlorobenzotriazoleHCID 12766262HCID 12766262, compound

Product 1

HCID 127662663-Chloro-7-(4-pyridyl)pyrazolo[1,5-a]pyrimidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 0.01 mole of 7-(4-pyridyl)pyrazolo[1,5-a]pyrimidine in cold dichloromethane is added 0.011 mole of N-chlorobenzotriazole. The mixture is stirred at room temperature for one hour and heated on a steam bath for 15 minutes. The product is worked up as for Example 62 to give the product of the example, m.p. 183°-184° C.

Workup

  1. temperatureheated on a steam bath for 15 minutes
  2. customto give the product of the example, m.p. 183°-184° C.

Sources & evidence

ORD record
ord-e4b7236d8f354141876d6fa97b91a4e0
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

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