Ethanol → HCID 21163158, compound

HRID 1278270Notes

Reaction equation

HRID 1278270 reaction equation
[CH2:1]([C:8]1[CH:24]=[CH:23][C:11]2[C:12](=[O:22])[CH:13]=[C:14]([CH2:16][CH2:17][C:18]([O:20]C)=[O:19])[O:15][C:10]=2[C:9]=1[CH2:25][CH2:26][CH3:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)C.C(=O)([O-])[O-].[Na+].[Na+]>O>[CH2:1]([C:8]1[CH:24]=[CH:23][C:11]2[C:12](=[O:22])[CH:13]=[C:14]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[O:15][C:10]=2[C:9]=1[CH2:25][CH2:26][CH3:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 10340Sodium CarbonateHCID 21163151HCID 21163151, compound

Product 1

HCID 21163158HCID 21163158, compoundYield 72.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Methyl 3-[7-benzyl-4-oxo-8-propyl-4H-1-benzopyran-2-yl]propionate (1.0 g) was refluxed with ethanol (50 ml) containing 10% aqueous sodium carbonate solution (10 ml) for 30 minutes. The mixture was diluted with water, washed with ethyl acetate, and acidified to give a solid, which crystallised from ethanol to give the propionic acid (0.7 g), mp 160°-161°.

Workup

  1. washwashed with ethyl acetate
  2. customto give a solid, which
  3. customcrystallised from ethanol

Sources & evidence

ORD record
ord-03d5c5690a4843ceb0e71d6cc9a6f612
Source dataset
uspto-grants-1981_07
Patent number
US04281008

Reaction notes

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