Hydrochloric Acid → HCID 21163444, compound

HRID 1278299Notes

Reaction equation

HRID 1278299 reaction equation
[CH2:1]([NH:4][C:5]1[CH:17]=[CH:16][C:8]([CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])=[CH:7][CH:6]=1)[CH:2]=[CH2:3].[OH-].[K+].C(O)C.Cl>O>[CH2:1]([NH:4][C:5]1[CH:17]=[CH:16][C:8]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:7][CH:6]=1)[CH:2]=[CH2:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 21163421HCID 21163421, compound

Product 1

HCID 21163444HCID 21163444, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 4 g. sample of ethyl 4-(allylamino)hydrocinnamate is hydrolyzed with 1.6 g. 85% potassium hydroxide in 60 ml. 95% ethanol by refluxing the solution for 5 hours. The solution is cooled, diluted with 100 ml. water and acidified to pH 4.5 with 37% hydrochloric acid. The precipitate is collected, dried in vacuo and crystallized from acetone to yield the title compound as white powder.

Workup

  1. temperatureThe solution is cooled
  2. additiondiluted with 100 ml
  3. customThe precipitate is collected
  4. customdried in vacuo
  5. customcrystallized from acetone

Sources & evidence

ORD record
ord-0a0cfd2ab1f747d9aaf8799823f16e4c
Source dataset
uspto-grants-1981_07
Patent number
US04281019

Reaction notes

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