Dichloromethane → HCID 21163430, compound

HRID 1278311Notes

Reaction equation

HRID 1278311 reaction equation
Cl.[CH2:2]([NH:5][C:6]1[CH:16]=[CH:15][C:9]([CH2:10][CH2:11][C:12](Cl)=[O:13])=[CH:8][CH:7]=1)[CH:3]=[CH2:4].C(Cl)Cl.[OH:20][CH:21]([CH2:26][CH3:27])[C:22]([O:24][CH3:25])=[O:23].C(N(CC)CC)C>CCOCC>[CH2:2]([NH:5][C:6]1[CH:16]=[CH:15][C:9]([CH2:10][CH2:11][C:12]([O:20][CH:21]([C:22]([O:24][CH3:25])=[O:23])[CH2:26][CH3:27])=[O:13])=[CH:8][CH:7]=1)[CH:3]=[CH2:4]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 520445Methyl 2-hydroxybutanoateHCID 21163403HCID 21163403, compound

Product 1

HCID 21163430HCID 21163430, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 10.0 g. 4-(allylamino)hydrocinnamoyl chloride hydrochloride in 200 ml. methylene chloride is added dropwise a solution of 3 g. methyl 2-hydroxybutyrate and 5 g. triethylamine in 100 ml. ether. After 17 hours stirring at room temperature, the precipitate is collected and washed with several portions of ether. The ether solution is washed with water, dried and evaporated to yield 1-(methoxycarbonyl)propyl 4-(allylamino)hydrocinnamate as a white solid.

Workup

  1. customthe precipitate is collected
  2. washwashed with several portions of ether
  3. washThe ether solution is washed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-939adff82fb240dab1d5e760f0f48a6c
Source dataset
uspto-grants-1981_07
Patent number
US04281019

Reaction notes

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