Piperidine → HCID 178430806, compound

HRID 1278316Notes

Reaction equation

HRID 1278316 reaction equation
[C:1]([NH:4][C:5]([NH2:7])=[S:6])(=[NH:3])[NH2:2].N1CC[CH2:11][CH2:10][CH2:9]1>CC(C)=O>[NH2:3][C:1]1[NH:2][C:10]([CH3:11])([CH3:9])[N:7]=[C:5]([SH:6])[N:4]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 178513045HCID 178513045, compound

Product 1

HCID 178430806HCID 178430806, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In the 200 ml of acetone was refluxed for 3 hours 7.1 g (0.06 mole) of amidinothiourea in the presence of 6 ml of piperidine. After having been allowed to cool, the reaction mixture was filtered to collect 7.6 g (in 80% yield) of colorless powder as deposited. Recrystallization from alcohol gave 7.0 g (in 74% yield) of colorless branch-like crystals, m.p. 186.5°-187.5° C.

Workup

  1. temperatureto cool
  2. filtrationthe reaction mixture was filtered
  3. customto collect 7.6 g (in 80% yield) of colorless powder
  4. customRecrystallization from alcohol
  5. customgave 7.0 g (in 74% yield) of colorless branch-like crystals, m.p. 186.5°-187.5° C.

Sources & evidence

ORD record
ord-5a6f3727d7c647be8948f76c673c0a84
Source dataset
uspto-grants-1981_07
Patent number
US04281059

Reaction notes

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