Hydrochloric Acid → HCID 12881326, compound

HRID 1278358Notes

Reaction equation

HRID 1278358 reaction equation
C[O:2][C:3](=[O:23])/[CH:4]=[CH:5]/[N:6]1[C:15](=[O:16])[C:14]2[C:9](=[C:10]([CH:20]([CH3:22])[CH3:21])[CH:11]=[C:12]([CH:17]([CH3:19])[CH3:18])[CH:13]=2)[N:8]=[CH:7]1.Cl>O>[CH:17]([C:12]1[CH:13]=[C:14]2[C:9](=[C:10]([CH:20]([CH3:22])[CH3:21])[CH:11]=1)[N:8]=[CH:7][N:6](/[CH:5]=[CH:4]/[C:3]([OH:23])=[O:2])[C:15]2=[O:16])([CH3:18])[CH3:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12881313HCID 12881313, compound

Product 1

HCID 12881326HCID 12881326, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.15 g. of trans-3-(6,8-diisopropyl-4-oxo-4H-quinazolin-3-yl)-2-propenoic acid methyl ester and 50 ml. of 6 N hydrochloric acid was stirred and refluxed for 20 minutes. After cooling to room temperature, 100 ml. of water was added and the reaction mixture was cooled and filtered to yield 0.60 g, mp 181°-182° of pure trans-3-(6,8-diisopropyl-4-oxo-4H-quinazolin-3-yl)-2-propenoic acid.

Workup

  1. additionA mixture of 1.15 g
  2. temperaturerefluxed for 20 minutes
  3. temperaturethe reaction mixture was cooled
  4. filtrationfiltered

Sources & evidence

ORD record
ord-d08a7652c5d9494290fc385791b9b24f
Source dataset
uspto-grants-1981_07
Patent number
US04281127

Reaction notes

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