Hydrazine hydrate (1:1) → HCID 12814340, compound

HRID 127838Notes

Reaction equation

HRID 127838 reaction equation
CO[C:3](=[O:26])[C@H:4]([CH2:24][OH:25])[NH:5][C:6](=[O:23])[C@H:7]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10].O.[NH2:28][NH2:29]>CO>[C:12]([O:11][C:9]([NH:8][C@H:7]([C:6]([NH:5][C@H:4]([C:3]([NH:28][NH2:29])=[O:26])[CH2:24][OH:25])=[O:23])[CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:10])([CH3:13])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10595049HCID 10595049, compound

Product 1

HCID 12814340HCID 12814340, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

18.3 g of tert-butyloxycarbonyl-L-phenylalanyl-L-serine methyl ester were dissolved in 50 ml of methyl alcohol, and to this solution 7.5 ml of 80% hydrazine mono hydrate were added. The mixture was stirred for 15 hours at room temperature and then the reaction mixture was concentrated under reduced pressure to give a solid substance. The solid substance was allowed to re-crystallization with ethyl alcohol and thereby tert-butyloxycarbonyl-L-phenylalanyl-L-serine hydrazide was obtained.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customto give a solid substance
  3. customThe solid substance was allowed to re-crystallization with ethyl alcohol

Sources & evidence

ORD record
ord-c28ad5b79f3a4b759d71629be40ad4f6
Source dataset
uspto-grants-1981_03
Patent number
US04257939

Reaction notes

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