反应详情

A solution of 12 g. of 4-aminobenzonitrile and 15 g. of methyl 16-bromohexadecanoate in 200 ml. of hexamethylphosphoramide is heated at 120° for 22 hours, allowed to cool, and diluted with water. The mixture is chilled and the precipitate which forms is collected, dried, and recrystallized from etherhexane to yield 4-(15-carbomethoxypentadecylamino)benzonitrile as a white solid.

1. temperatureto cool
2. temperatureThe mixture is chilled
3. customthe precipitate which forms is collected
4. customdried
5. customrecrystallized from etherhexane