反应详情

A flask containing 10.0 g. 4-(15-carbomethoxypentadecylamino)benzoic acid, 3.3 g. lactic acid, 500 mg. toluenesulfonic acid and 500 ml. toluene is equipped with a Soxhlet extractor charged with activated 4 A Linde molecular sieves. The solution is refluxed for 4 hours, during which time the Soxhlet extractor is charged twice more with fresh sieves. The hot solution is filtered and left to cool, whereupon the product separates as off-white crystals.

1. additionA flask containing 10.0 g
2. additioncharged
3. temperatureThe solution is refluxed for 4 hours, during which time the Soxhlet extractor
4. additionis charged twice more with fresh sieves
5. filtrationThe hot solution is filtered
6. waitleft
7. temperatureto cool, whereupon the product