HRID12785

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：Cc1nc(F)ccc1-c1cn(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)c(=O)[nH]c1=O

HCID24759549

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(F)ccc1-c1cn(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)c(=O)[nH]c1=O.Cl.Cl

HCID86615956

未命名化合物

收率 5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

PROCEDURE

实验过程

5-(6-fluoro-2-methyl-3-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (7 mg) was dissolved in dioxane and then treated with a solution of 4N HCl in dioxane (2 eq) to give the title compound as an off-white powder (8 mg, 5% yield)