HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 17887402, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Bromo-5-chloropentane | HCID 96070 | — |
| Reactant | HCID 178418793 | HCID 178418793 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 17887402 | HCID 17887402 | 52% |
Reaction Steps
2.8 g (25=mol) of 2-mercaptopyrimidine, 4.64 g (25 mmol) of 1-bromo-5-chloropentane and 2.58 g (25.5 mmol) of triethylamine in 100 ml of THF were refluxed for 4 hours. After cooling, filtration with suction and concentration, the residue was purified by chromatography (mobile phase: cyclohexane/ethyl acetate=92/8). 2.8 g of product were obtained (=52% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06444674B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-0a30eada12cb45fcb73b20f7b3307dec |
| Source note | uspto-grants-2002_09 |