Triethylamine → HCID 17887402, compound

HRID 1278560Notes

Reaction equation

HRID 1278560 reaction equation
[SH:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.Br[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][Cl:14].C(N(CC)CC)C>C1COCC1>[Cl:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][S:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 960701-Bromo-5-chloropentaneHCID 178418793HCID 178418793, compound

Product 1

HCID 17887402HCID 17887402, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.8 g (25=mol) of 2-mercaptopyrimidine, 4.64 g (25 mmol) of 1-bromo-5-chloropentane and 2.58 g (25.5 mmol) of triethylamine in 100 ml of THF were refluxed for 4 hours. After cooling, filtration with suction and concentration, the residue was purified by chromatography (mobile phase: cyclohexane/ethyl acetate=92/8). 2.8 g of product were obtained (=52% yield).

Workup

  1. temperatureAfter cooling
  2. filtrationfiltration
  3. concentrationwith suction and concentration
  4. customthe residue was purified by chromatography (mobile phase: cyclohexane/ethyl acetate=92/8)

Sources & evidence

ORD record
ord-0a30eada12cb45fcb73b20f7b3307dec
Source dataset
uspto-grants-2002_09
Patent number
US06444674B1

Reaction notes

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