Hydrazine hydrate (1:1) → 4-Methyl-1,3-thiazole-2-carbohydrazide

HRID 1278567Notes

Reaction equation

HRID 1278567 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:7]([O:9]C)=O)[S:5][CH:6]=1.O.[NH2:12][NH2:13]>CO>[CH3:1][C:2]1[N:3]=[C:4]([C:7]([NH:12][NH2:13])=[O:9])[S:5][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11435075Methyl 4-methylthiazole-2-carboxylate

Product 1

HCID 112289374-Methyl-1,3-thiazole-2-carbohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 4-methyl-2-thiazole carboxylate (step a, 2.1 g) in methanol (20 ml) was added hydrazine hydrate (3.2 ml) dropwise over 30 mins. The reaction mixture was stirred for 1.5 hours and the precipitate filtered off to yield the title compound as a white solid (1.6 g). 1H NMR (250 MHz, DMSO) 8 2.64 (3H, s), 4.82 (2H, bs), 7.79 (1H, s), 10.25 (1H, bs).

Workup

  1. filtrationthe precipitate filtered off

Sources & evidence

ORD record
ord-f653e096f6c242f0aec4fa0700fde9b8
Source dataset
uspto-grants-2002_09
Patent number
US06444666B1

Reaction notes

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