HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86615957, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(3-{(1R,5R)-1-methyl-5-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[6-(trifluoromethyl)-2-pyridinyl]-2,4(1H,3H)-pyrimidinedione | HCID 86615958 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86615957 | HCID 86615957 | 15% |
Reaction Steps
1-(3-{(1R,5R)-1-methyl-5-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[6-(trifluoromethyl)-2-pyridinyl]-2,4(1H,3H)-pyrimidinedione was dissolved in dioxane and then treated with a solution of 4N HCl in dioxane (2 eq) to give the title compound as a brown oil (23 mg, 15%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-05c8bd41c7644f5c9f23bf140d398f6c |
| Source note | uspto-grants-2010_06 |