Hydrochloric Acid → HCID 86615957, compound

HRID 12787Notes

Reaction equation

HRID 12787 reaction equation
[CH3:1][C@@:2]12[CH2:7][C@:6]1([C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1)[CH2:5][N:4]([CH2:18][CH2:19][CH2:20][N:21]1[CH:26]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[N:28]=3)[C:24](=[O:37])[NH:23][C:22]1=[O:38])[CH2:3]2.[ClH:39]>O1CCOCC1>[ClH:39].[ClH:39].[CH3:1][C@@:2]12[CH2:7][C@:6]1([C:8]1[CH:9]=[CH:10][C:11]([C:14]([F:15])([F:16])[F:17])=[CH:12][CH:13]=1)[CH2:5][N:4]([CH2:18][CH2:19][CH2:20][N:21]1[CH:26]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[N:28]=3)[C:24](=[O:37])[NH:23][C:22]1=[O:38])[CH2:3]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 866159581-(3-{(1R,5R)-1-methyl-5-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[6-(trifluoromethyl)-2-pyridinyl]-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 86615957HCID 86615957, compoundYield 15%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1-(3-{(1R,5R)-1-methyl-5-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[6-(trifluoromethyl)-2-pyridinyl]-2,4(1H,3H)-pyrimidinedione was dissolved in dioxane and then treated with a solution of 4N HCl in dioxane (2 eq) to give the title compound as a brown oil (23 mg, 15%).

Sources & evidence

ORD record
ord-05c8bd41c7644f5c9f23bf140d398f6c
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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