反应详情

1 Eq. of 2-methylthio-5-ethoxycarbonylpyrimidine were dissolved in dioxane and, after addition of 2 eq. of 2N LiOH, stirred overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in EtOH. After addition of a stoichiometric amount of ethereal HCl, the solution was again evaporated to dryness. Water which was still present was removed by azeotropic drying with toluene once.

1. customThe solvent was then removed under reduced pressure
2. dissolutionthe residue was dissolved in EtOH
3. additionAfter addition of a stoichiometric amount of ethereal HCl
4. customthe solution was again evaporated to dryness
5. customWater which was still present was removed
6. dry with materialby azeotropic drying with toluene once