Hydrochloric Acid → HCID 12052987, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 2-methyl-3-[1-phenylpyrrol-2-yl]propanoate (0.164 mol, 42.1 g) and Claisen's reagent (78 ml) were heated at 90-95° C. for 1 h. After cooling to room temperature, the solution was diluted with 75 g of crushed ice and acidified to pH 1-2 with 6 N HCl. The brown oily precipitate was dissolved in ether, washed with brine solution, dried over MgSO4, and evaporated to an orange oil (21.65 g). The title compound was analysed by 1H-NMR spectroscopy.

Provenance & Evidence