Hydrochloric Acid → HCID 12052987, compound

HRID 1278957Notes

Reaction equation

HRID 1278957 reaction equation
[CH3:1][CH:2]([CH2:8][C:9]1[N:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:11]=[CH:12][CH:13]=1)[C:3]([O:5]CC)=[O:4].Cl>CCOCC>[CH3:1][CH:2]([CH2:8][C:9]1[N:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:11]=[CH:12][CH:13]=1)[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12974058HCID 12974058, compound

Product 1

HCID 12052987HCID 12052987, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
92.5 °C

Procedure

A mixture of ethyl 2-methyl-3-[1-phenylpyrrol-2-yl]propanoate (0.164 mol, 42.1 g) and Claisen's reagent (78 ml) were heated at 90-95° C. for 1 h. After cooling to room temperature, the solution was diluted with 75 g of crushed ice and acidified to pH 1-2 with 6 N HCl. The brown oily precipitate was dissolved in ether, washed with brine solution, dried over MgSO4, and evaporated to an orange oil (21.65 g). The title compound was analysed by 1H-NMR spectroscopy.

Workup

  1. temperatureAfter cooling to room temperature
  2. washwashed with brine solution
  3. dry with materialdried over MgSO4
  4. customevaporated to an orange oil (21.65 g)

Sources & evidence

ORD record
ord-f1da112343894530bb30c71555bc4e26
Source dataset
uspto-grants-2002_09
Patent number
US06444833B1

Reaction notes

Loading…