反应详情

To a stirred suspension of 1.23 g of 1f in 40 mL of tetrahydrofuran and 15 mL of methanol was added 217 mg sodium borohydride in small portions. After stirring the mixture at ambient temperature for 5 min, 50 mL of water was added and tetrahydrofuran and methanol were removed in vacuo. Brine was added and the mixture was extracted with ethyl acetate. The ethyl acetate extract was dried (MgSO4) and concentrated under reduced pressure giving 1.27 g of 1g. 1H-NMR 200 MHz (CDCl3) δ: 4.75 (2H, s), 6.95 (1H, br.s), 7.30-7.55 (7H, m), 8.25-8.38 (2H, m), 8.69 (1H, br.s).

1. customtetrahydrofuran and methanol were removed in vacuo
2. additionBrine was added
3. extractionthe mixture was extracted with ethyl acetate
4. extractionThe ethyl acetate extract
5. dry with materialwas dried (MgSO4)
6. concentrationconcentrated under reduced pressure