N-(6-formyl-1-isoquinolinyl)benzamide → N-(7-Formylisoquinolinyl)benzamide

HRID 1279021Notes

Reaction equation

HRID 1279021 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[NH:12][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1.[CH:21](C1C=C2C(=CC=1)C(NC(=O)C1C=CC=CC=1)=NC=C2)=[O:22]>>[CH:21]([C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[NH:12][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1)=[O:22]

Participants

3

Reactant 2

HCID 22665740N-(6-formyl-1-isoquinolinyl)benzamideHCID 22665843N-(7-bromo-1-isoquinolinyl)benzamide

Product 1

HCID 22665912N-(7-Formylisoquinolinyl)benzamide

Procedure

N-(7-Formylisoquinolinyl)benzamide was prepared from 37e using the procedure described for 1f but was not purified using column chromatography. The crude aldehyde was transformed into the title compound using the procedure described for 1 g folowed by purification using column chromatography on silica gel (toluene/ethyl acetate:2/1). M.p. 137.5-139.0° C.

Workup

  1. customwas not purified
  2. customfolowed by purification

Sources & evidence

ORD record
ord-090c2f6d29f0443797bbf76b7d791d42
Source dataset
uspto-grants-2002_09
Patent number
US06444672B1

Reaction notes

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