反应详情

A solution of 11-mercaptoundecanoic acid (300 mg, 1.3 mmol) and diphenylmethanol (255 mg, 1.3 mmol) in trifluoroacetic acid was stirred at RT, under nitrogen for 30 min. Trifluoroacetic acid was evaporated under high vacuum, the residue dissolved in ether (20 ml), washed with water (3×20 ml), dried and evaporated. The residue was purified by chromatography (light pet—ethyl acetate, 80:20-50:50) on silica to give the desired product (220 mg, 42%), m.p. (Found C, 74.55; H, 8.77. C24H34O2S requires C, 74.96; H, 8.39) ms (EI) 384.

1. customTrifluoroacetic acid was evaporated under high vacuum
2. dissolutionthe residue dissolved in ether (20 ml)
3. washwashed with water (3×20 ml)
4. customdried
5. customevaporated
6. customThe residue was purified by chromatography (light pet—ethyl acetate, 80:20-50:50) on silica