反应详情

A mixture of 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one (0.05 mol) prepared as described in Eβ-A-0,006,711, 3-bromo-2-pentanone (0.073 mol) and K2CO3 (10 g) in DMF (200 ml) and toluene (200 ml) was stirred and refluxed overnight using a water separator. The solvent was evaporated. The residue was dissolved in CH2Cl2. The organic solution was washed, dried, filtered and the solvent was evaporated. The residue was crystallized from 2-propanol. The precipitate was filtered off and the filtrate was evaporated. The residue was triturated in DIPE, filtered off and dried, yielding 4.6 g of (±)-2-(1-ethyl-2-oxopropyl)-2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one (intermn.

1. customprepared
2. temperaturerefluxed overnight
3. customThe solvent was evaporated
4. dissolutionThe residue was dissolved in CH2Cl2
5. washThe organic solution was washed
6. customdried
7. filtrationfiltered
8. customthe solvent was evaporated
9. customThe residue was crystallized from 2-propanol
10. filtrationThe precipitate was filtered off
11. customthe filtrate was evaporated
12. customThe residue was triturated in DIPE
13. filtrationfiltered off
14. customdried