Ethanol → HCID 18427787, compound

HRID 1279285Notes

Reaction equation

HRID 1279285 reaction equation
[Na].[O:2]1CCO[CH2:4][CH2:3]1.CS[C:10](SC)=[C:11]([C:14](=[O:25])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=1)[C:12]#[N:13].[CH2:28]([OH:30])[CH3:29]>>[CH2:3]([O:2][C:10]([O:30][CH2:28][CH3:29])=[C:11]([C:14](=[O:25])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=1)[C:12]#[N:13])[CH3:4]

Participants

5

Reactant 4

HCID 702EthanolHCID 312751,4-DioxaneHCID 27360473,3-Bis(methylsulfanyl)-2-[3-(trifluoromethyl)benzoyl]prop-2-enenitrileHCID 5360545Sodium

Product 1

HCID 18427787HCID 18427787, compound

Procedure

Sodium (0.126 g, 5.5 mmol) was dissolved in 15 mL of ethanol and 20 mL of dioxane was added followed by 1.59 g (5.0 mmol) of 3,3-bis-methylthio-2-(3-trifluoromethylbenzoyl)-acrylonitrile and the reaction mixture was refluxed for 4 hours and let stir overnight at room temperature. This compound was relatively unstable to aqueous conditions and was not isolated as such. Instead, an aliquot of the mixture was stripped and the product was identified by 300 MHz proton NMR: NMR (DMSO-d6): 1.14 (6H, tJ=7), 3.45 (4H, q, J=7), 7.44-8.16 (4H, m).

Workup

  1. temperaturethe reaction mixture was refluxed for 4 hours
  2. customwas not isolated as such

Sources & evidence

ORD record
ord-28b5dae529fe4f45a063b619d525ad7e
Source dataset
uspto-grants-2002_09
Patent number
US06448265B1

Reaction notes

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