2-Aminophenol → 5-p-Chlorophenyl-1-phenyl-4-(benzoxazol-2-ylmethyl)-pyrazole

HRID 127940Notes

Reaction equation

HRID 127940 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:11]=[CH:10][C:9]=2[CH2:19][C:20](O)=[O:21])=[CH:4][CH:3]=1.[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:11]=[CH:10][C:9]=2[CH2:19][C:20]2[O:21][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[N:23]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58012-AminophenolHCID 622583Pyrazole-4-acetic acid, 5-(p-chlorophenyl)-1-phenyl-

Product 1

HCID 234708615-p-Chlorophenyl-1-phenyl-4-(benzoxazol-2-ylmethyl)-pyrazole

Procedure

A mixture of 31.3 g of (5-p-chlorophenyl-1-phenyl-pyrazol-4-yl)-acetic acid, 10.9 g of o-aminophenol and 400 ml of polyphosphoric acid is heated at 175° for 2 hours. After cooling and the customary working up, 5-p-chlorophenyl-1-phenyl-4-(benzoxazol-2-ylmethyl)-pyrazole is obtained; m.p. 137°-139°.

Workup

  1. temperatureis heated at 175° for 2 hours
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-053e0840cb7740cf8b8fe79c0da37555
Source dataset
uspto-grants-1981_03
Patent number
US04258047

Reaction notes

Loading…