Hydrochloric Acid → HCID 18770417, compound
Reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:14]=[CH:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][N:31]([C:34](=[O:51])/[CH:35]=[CH:36]/[CH:37]=[CH:38]/[C:39]4[CH:44]=[C:43]([O:45][CH3:46])[C:42]([O:47][CH3:48])=[C:41]([O:49][CH3:50])[CH:40]=4)[CH2:30][CH2:29]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[ClH:1].[CH3:46][O:45][C:43]1[CH:44]=[C:39](/[CH:38]=[CH:37]/[CH:36]=[CH:35]/[C:34]([N:31]2[CH2:32][CH2:33][N:28]([CH2:27][CH2:26][N:23]3[CH2:22][CH2:21][N:20]([C:18](=[O:19])/[CH:17]=[CH:16]/[CH:15]=[CH:14]/[C:6]4[CH:7]=[C:8]([O:12][CH3:13])[C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=4)[CH2:25][CH2:24]3)[CH2:29][CH2:30]2)=[O:51])[CH:40]=[C:41]([O:49][CH3:50])[C:42]=1[O:47][CH3:48]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.050 ml; 0.60 mmol) was added to a solution in ethanol (5 ml) of 1,2- bis[4-[(E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-1-piperazinyl]ethane (128 mg; 0.19 nmmol) synthesized in the above process and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methanoldiethyl ether to obtain the title compound as a pale yellow crystalline powder.
Workup
- customsynthesized in the above process
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
- customthe resultant concentrated residue was recrystallized from methanoldiethyl ether
Sources & evidence
- ORD record
- ord-26a3e5cf215a48009f00b2ba18a482b9
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06448242B1
Reaction notes
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