Hydrochloric Acid → HCID 9940493, compound
Reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:14]=[CH:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][CH2:28][N:29]3[CH2:34][CH2:33][N:32]([C:35](=[O:52])/[CH:36]=[CH:37]/[CH:38]=[CH:39]/[C:40]4[CH:45]=[C:44]([O:46][CH3:47])[C:43]([O:48][CH3:49])=[C:42]([O:50][CH3:51])[CH:41]=4)[CH2:31][CH2:30]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[ClH:1].[CH3:47][O:46][C:44]1[CH:45]=[C:40](/[CH:39]=[CH:38]/[CH:37]=[CH:36]/[C:35]([N:32]2[CH2:33][CH2:34][N:29]([CH2:28][CH2:27][CH2:26][N:23]3[CH2:22][CH2:21][N:20]([C:18](=[O:19])/[CH:17]=[CH:16]/[CH:15]=[CH:14]/[C:6]4[CH:7]=[C:8]([O:12][CH3:13])[C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=4)[CH2:25][CH2:24]3)[CH2:30][CH2:31]2)=[O:52])[CH:41]=[C:42]([O:50][CH3:51])[C:43]=1[O:48][CH3:49]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.040 ml; 0.48 mmol) was added to a solution of 1,3-bis[4-[(E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-1-piperazinyl]propane (130 mg; 0.19 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methanol-diethyl ether to obtain the title compound as a pale yellow crystalline powder.
Workup
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
- customthe resultant concentrated residue was recrystallized from methanol-diethyl ether
Sources & evidence
- ORD record
- ord-87339f5e9c844a2bb73d0d030d6e29d3
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06448242B1
Reaction notes
Loading…