Hydrochloric Acid → HCID 18770436, compound

HRID 1279448Notes

Reaction equation

HRID 1279448 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:47]2[CH:52]=[C:51]([O:53][CH3:54])[C:50]([O:55][CH3:56])=[C:49]([O:57][CH3:58])[CH:48]=2)=[C:7]([CH:46]=1)[C:8]([N:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][N:22]([C:25](=[O:45])[C:26]3[CH:31]=[C:30]([NH2:32])[CH:29]=[CH:28][C:27]=3[C:33]3[CH:38]=[C:37]([O:39][CH3:40])[C:36]([O:41][CH3:42])=[C:35]([O:43][CH3:44])[CH:34]=3)[CH2:21][CH2:20]2)[CH2:12][CH2:11]1)=[O:9]>C(O)C>[ClH:1].[ClH:1].[NH2:32][C:30]1[CH:29]=[CH:28][C:27]([C:33]2[CH:34]=[C:35]([O:43][CH3:44])[C:36]([O:41][CH3:42])=[C:37]([O:39][CH3:40])[CH:38]=2)=[C:26]([CH:31]=1)[C:25]([N:22]1[CH2:23][CH2:24][N:19]([CH2:18][CH2:17][CH2:16][N:13]2[CH2:14][CH2:15][N:10]([C:8](=[O:9])[C:7]3[CH:46]=[C:3]([NH2:2])[CH:4]=[CH:5][C:6]=3[C:47]3[CH:48]=[C:49]([O:57][CH3:58])[C:50]([O:55][CH3:56])=[C:51]([O:53][CH3:54])[CH:52]=3)[CH2:11][CH2:12]2)[CH2:20][CH2:21]1)=[O:45]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15491073HCID 15491073, compound

Product 1

HCID 18770436HCID 18770436, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.020 ml; 0.24 mmol) was added to a solution of 1,3-bis[4-[5-amino-2-(3,4,5-trimethoxyphenyl)benzoyl]-1-piperazinyl]propane (29 mg; 0.030 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methylene chloride-diethyl ether to obtain the title compound as a pale yellow crystalline powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
  3. customthe resultant concentrated residue was recrystallized from methylene chloride-diethyl ether

Sources & evidence

ORD record
ord-8a1e2962bbe049b7b6757ca2e521c6b7
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

Loading…