Hydrochloric Acid → HCID 18770404, compound
Reaction equation
[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[CH:14]=[CH:15]/[C:16]([N:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][N:32]3[CH2:37][CH2:36][N:35]([C:38](=[O:53])/[CH:39]=[CH:40]/[CH:41]=[CH:42]/[C:43]4[CH:48]=[CH:47][C:46]([C:49]([CH3:52])([CH3:51])[CH3:50])=[CH:45][CH:44]=4)[CH2:34][CH2:33]3)[CH2:20][CH2:19]2)=[O:17])=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3]>C(O)C>[ClH:1].[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[CH:14]=[CH:15]/[C:16]([N:18]2[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][N:32]3[CH2:33][CH2:34][N:35]([C:38](=[O:53])/[CH:39]=[CH:40]/[CH:41]=[CH:42]/[C:43]4[CH:48]=[CH:47][C:46]([C:49]([CH3:52])([CH3:51])[CH3:50])=[CH:45][CH:44]=4)[CH2:36][CH2:37]3)[CH2:22][CH2:23]2)=[O:17])=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.050 ml; 0.60 mmol) was added to a solution of 1,8-bis[4-[(E,E)-5-(4-tert-butylphenyl)-2,4-pentadienoyl]-1-piperazinyl]octane (105 mg; 0.14 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methanol-diethyl ether to obtain the title compound as a colorless crystalline powder.
Workup
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
- customthe resultant concentrated residue was recrystallized from methanol-diethyl ether
Sources & evidence
- ORD record
- ord-2530624651704750a9c289b386a2d322
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06448242B1
Reaction notes
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