Hydrochloric Acid → HCID 18770433, compound
Reaction equation
[ClH:1].[CH3:2][C:3]1[CH:4]=[C:5](/[CH:11]=[CH:12]/[CH:13]=[CH:14]/[C:15]([N:17]2[CH2:22][CH2:21][N:20]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][N:31]4[CH2:36][CH2:35][N:34]([C:37](=[O:51])/[CH:38]=[CH:39]/[CH:40]=[CH:41]/[C:42]5[CH:47]=[C:46]([CH3:48])[C:45]([CH3:49])=[C:44]([CH3:50])[CH:43]=5)[CH2:33][CH2:32]4)=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)=[O:16])[CH:6]=[C:7]([CH3:10])[C:8]=1[CH3:9]>C(O)C>[ClH:1].[ClH:1].[CH3:48][C:46]1[CH:47]=[C:42](/[CH:41]=[CH:40]/[CH:39]=[CH:38]/[C:37]([N:34]2[CH2:35][CH2:36][N:31]([CH2:30][C:27]3[CH:28]=[CH:29][C:24]([CH2:23][N:20]4[CH2:19][CH2:18][N:17]([C:15](=[O:16])/[CH:14]=[CH:13]/[CH:12]=[CH:11]/[C:5]5[CH:4]=[C:3]([CH3:2])[C:8]([CH3:9])=[C:7]([CH3:10])[CH:6]=5)[CH2:22][CH2:21]4)=[CH:25][CH:26]=3)[CH2:32][CH2:33]2)=[O:51])[CH:43]=[C:44]([CH3:50])[C:45]=1[CH3:49]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.050 ml; 0.60 mmol) was added to a solution of 1,4-bis[[4-[(E,E)-5-(3,4,5-trimethylphenyl)-2,4-pentadienoyl]-1-piperazinyl]-methyl]benzene (100 mg; 0.14 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methanol-diethyl ether to obtain 69 mg (yield: 47%) of the title compound as a colorless crystalline powder.
Workup
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
- customthe resultant concentrated residue was recrystallized from methanol-diethyl ether
Sources & evidence
- ORD record
- ord-c232ee7dfa9f411abde6e03173712de6
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06448242B1
Reaction notes
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