Hydrochloric Acid → HCID 18770450, compound

HRID 1279460Notes

Reaction equation

HRID 1279460 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:58]=[CH:57][C:17]([C:18]([N:20]3[CH2:26][CH2:25][CH2:24][N:23]([CH2:27][CH2:28][CH2:29][N:30]4[CH2:36][CH2:35][CH2:34][N:33]([C:37](=[O:56])[C:38]5[CH:43]=[CH:42][C:41]([C:44]6[CH:49]=[C:48]([O:50][CH3:51])[C:47]([O:52][CH3:53])=[C:46]([O:54][CH3:55])[CH:45]=6)=[CH:40][CH:39]=5)[CH2:32][CH2:31]4)[CH2:22][CH2:21]3)=[O:19])=[CH:16][CH:15]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[ClH:1].[CH3:51][O:50][C:48]1[CH:49]=[C:44]([C:41]2[CH:42]=[CH:43][C:38]([C:37]([N:33]3[CH2:34][CH2:35][CH2:36][N:30]([CH2:29][CH2:28][CH2:27][N:23]4[CH2:24][CH2:25][CH2:26][N:20]([C:18](=[O:19])[C:17]5[CH:57]=[CH:58][C:14]([C:6]6[CH:5]=[C:4]([O:3][CH3:2])[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=6)=[CH:15][CH:16]=5)[CH2:21][CH2:22]4)[CH2:31][CH2:32]3)=[O:56])=[CH:39][CH:40]=2)[CH:45]=[C:46]([O:54][CH3:55])[C:47]=1[O:52][CH3:53]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770401HCID 18770401, compound

Product 1

HCID 18770450HCID 18770450, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.025 ml; 0.30 mmol) was added to a solution of 1,1′-trimethylenedi[4-[4-(3,4,5-trimethoxyphenyl)benzoyl]hexahydro-1,4-diazepine](46 mg; 0.060 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. The concentrated residue was suspended in diethyl ether and collected by filtration to obtain the title compound as a colorless crystalline powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-c31e692e18164bb48c12a33ead9c69e9
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

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