Hydrochloric Acid → HCID 18770435, compound
Reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:14]=[CH:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:26][CH2:25][CH2:24][N:23]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][N:35]3[CH2:41][CH2:40][CH2:39][N:38]([C:42](=[O:59])/[CH:43]=[CH:44]/[CH:45]=[CH:46]/[C:47]4[CH:52]=[C:51]([O:53][CH3:54])[C:50]([O:55][CH3:56])=[C:49]([O:57][CH3:58])[CH:48]=4)[CH2:37][CH2:36]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[ClH:1].[CH3:54][O:53][C:51]1[CH:52]=[C:47](/[CH:46]=[CH:45]/[CH:44]=[CH:43]/[C:42]([N:38]2[CH2:39][CH2:40][CH2:41][N:35]([CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][N:23]3[CH2:24][CH2:25][CH2:26][N:20]([C:18](=[O:19])/[CH:17]=[CH:16]/[CH:15]=[CH:14]/[C:6]4[CH:7]=[C:8]([O:12][CH3:13])[C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=4)[CH2:21][CH2:22]3)[CH2:36][CH2:37]2)=[O:59])[CH:48]=[C:49]([O:57][CH3:58])[C:50]=1[O:55][CH3:56]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.030 ml; 0.36 mmol) was added to a solution of 1,1′-octamethylenedi[4-[(E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]hexahydro-1,4-diazepine] (76 mg; 0.095 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a pale yellow amorphous powder.
Workup
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
Sources & evidence
- ORD record
- ord-fca6c9fa0117429c8e8e6a278a79f8f9
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06448242B1
Reaction notes
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