Hydrochloric Acid → HCID 18770428, compound
Reaction equation
[ClH:1].[CH3:2][C:3]1[CH:49]=[CH:48][C:6]([C:7]([N:9]2[CH2:14][CH2:13][CH:12]([CH2:15][CH:16]([N:45]([CH3:47])[CH3:46])[CH2:17][CH:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:44])[C:25]4[CH:30]=[CH:29][C:28]([CH3:31])=[C:27]([C:32]5[CH:37]=[C:36]([O:38][CH3:39])[C:35]([O:40][CH3:41])=[C:34]([O:42][CH3:43])[CH:33]=5)[CH:26]=4)[CH2:20][CH2:19]3)[CH2:11][CH2:10]2)=[O:8])=[CH:5][C:4]=1[C:50]1[CH:55]=[C:54]([O:56][CH3:57])[C:53]([O:58][CH3:59])=[C:52]([O:60][CH3:61])[CH:51]=1>C(O)C>[ClH:1].[CH3:31][C:28]1[CH:29]=[CH:30][C:25]([C:24]([N:21]2[CH2:22][CH2:23][CH:18]([CH2:17][CH:16]([N:45]([CH3:47])[CH3:46])[CH2:15][CH:12]3[CH2:13][CH2:14][N:9]([C:7](=[O:8])[C:6]4[CH:48]=[CH:49][C:3]([CH3:2])=[C:4]([C:50]5[CH:55]=[C:54]([O:56][CH3:57])[C:53]([O:58][CH3:59])=[C:52]([O:60][CH3:61])[CH:51]=5)[CH:5]=4)[CH2:10][CH2:11]3)[CH2:19][CH2:20]2)=[O:44])=[CH:26][C:27]=1[C:32]1[CH:37]=[C:36]([O:38][CH3:39])[C:35]([O:40][CH3:41])=[C:34]([O:42][CH3:43])[CH:33]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.020 ml; 0.24 mmol) was added to a solution of 1,3-bis[1-[4-methyl-3-(3,4,5-trimethoxyphenyl)benzoyl]-4-piperidinyl]-2-(dimethylamino)propane (53 mg; 0.064 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a pale yellow amorphous powder.
Workup
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
Sources & evidence
- ORD record
- ord-1a62ac5b4ba84c06978a8b861796bc1c
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06448242B1
Reaction notes
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