Hydrochloric Acid → HCID 18770457, compound

HRID 1279467Notes

Reaction equation

HRID 1279467 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]#[C:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][CH:23]([CH2:26][CH:27]([N:53]([CH3:55])[CH3:54])[CH2:28][CH:29]3[CH2:34][CH2:33][N:32]([C:35](=[O:52])/[CH:36]=[CH:37]/[C:38]#[C:39][C:40]4[CH:45]=[C:44]([O:46][CH3:47])[C:43]([O:48][CH3:49])=[C:42]([O:50][CH3:51])[CH:41]=4)[CH2:31][CH2:30]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]#[C:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][CH:23]([CH2:26][CH:27]([N:53]([CH3:55])[CH3:54])[CH2:28][CH:29]3[CH2:34][CH2:33][N:32]([C:35](=[O:52])/[CH:36]=[CH:37]/[C:38]#[C:39][C:40]4[CH:41]=[C:42]([O:50][CH3:51])[C:43]([O:48][CH3:49])=[C:44]([O:46][CH3:47])[CH:45]=4)[CH2:31][CH2:30]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770458HCID 18770458, compound

Product 1

HCID 18770457HCID 18770457, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.035 ml; 0.42 mmol) was added to a solution of 1,3-bis[1-[(E)-5-(3,4,5trimethoxyphenyl)-2-penten-4-ynoyl]-4-piperidinyl]-2-(dimethylamino)propane (104 mg; 0.14 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a pale yellow amorphous powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure

Sources & evidence

ORD record
ord-19626e90345248109f8272d825a61ffb
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

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