Hydrochloric Acid → HCID 18770463, compound

HRID 1279471Notes

Reaction equation

HRID 1279471 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]#[C:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][CH:23]([CH2:26][CH:27]([CH2:53][N:54]([CH3:56])[CH3:55])[CH2:28][CH:29]3[CH2:34][CH2:33][N:32]([C:35](=[O:52])/[CH:36]=[CH:37]/[C:38]#[C:39][C:40]4[CH:45]=[C:44]([O:46][CH3:47])[C:43]([O:48][CH3:49])=[C:42]([O:50][CH3:51])[CH:41]=4)[CH2:31][CH2:30]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]#[C:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][CH:23]([CH2:26][CH:27]([CH2:53][N:54]([CH3:56])[CH3:55])[CH2:28][CH:29]3[CH2:34][CH2:33][N:32]([C:35](=[O:52])/[CH:36]=[CH:37]/[C:38]#[C:39][C:40]4[CH:41]=[C:42]([O:50][CH3:51])[C:43]([O:48][CH3:49])=[C:44]([O:46][CH3:47])[CH:45]=4)[CH2:31][CH2:30]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770420HCID 18770420, compound

Product 1

HCID 18770463HCID 18770463, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.020 ml; 0.24 mmol) was added to a solution of 1,3-bis[1-[(E)-5-(3,4,5-trimethoxyphenyl)-2-penten-4-ynoyl]-4-piperidinyl]-2-[(dimethylamino)methyl]propane (46 mg; 0.061 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a pale yellow amorphous powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure

Sources & evidence

ORD record
ord-2e2401fd049340a49d932b99088783c9
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

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