Hydrochloric Acid → HCID 18770411, compound

HRID 1279473Notes

Reaction equation

HRID 1279473 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:57]=[CH:56][C:17]([C:18]([N:20]3[CH2:25][CH2:24][CH:23]([CH2:26][N:27]([CH3:55])[CH2:28][CH:29]4[CH2:34][CH2:33][N:32]([C:35](=[O:54])[C:36]5[CH:41]=[CH:40][C:39]([C:42]6[CH:47]=[C:46]([O:48][CH3:49])[C:45]([O:50][CH3:51])=[C:44]([O:52][CH3:53])[CH:43]=6)=[CH:38][CH:37]=5)[CH2:31][CH2:30]4)[CH2:22][CH2:21]3)=[O:19])=[CH:16][CH:15]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[CH3:53][O:52][C:44]1[CH:43]=[C:42]([C:39]2[CH:38]=[CH:37][C:36]([C:35]([N:32]3[CH2:31][CH2:30][CH:29]([CH2:28][N:27]([CH3:55])[CH2:26][CH:23]4[CH2:22][CH2:21][N:20]([C:18](=[O:19])[C:17]5[CH:16]=[CH:15][C:14]([C:6]6[CH:5]=[C:4]([O:3][CH3:2])[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=6)=[CH:57][CH:56]=5)[CH2:25][CH2:24]4)[CH2:34][CH2:33]3)=[O:54])=[CH:41][CH:40]=2)[CH:47]=[C:46]([O:48][CH3:49])[C:45]=1[O:50][CH3:51]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770412HCID 18770412, compound

Product 1

HCID 18770411HCID 18770411, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.045 ml; 0.54 mmol) was added to a solution of N,N-bis[[1-[4-(3,4,5-trimethoxyphenyl)benzoyl]-4-piperidinyl]methyl]methylamine (142 mg; 0.18 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a colorless amorphous powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure

Sources & evidence

ORD record
ord-06b4b7a58b004e0391030d174473a925
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

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