Hydrochloric Acid → HCID 18770402, compound

HRID 1279477Notes

Reaction equation

HRID 1279477 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:53]=[CH:52][C:7]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][N:17]3[CH2:22][CH2:21][N:20]([CH2:23][CH:24]4[CH2:29][CH2:28][N:27]([C:30](=[O:51])[C:31]5[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([C:39]6[CH:44]=[C:43]([O:45][CH3:46])[C:42]([O:47][CH3:48])=[C:41]([O:49][CH3:50])[CH:40]=6)[CH:32]=5)[CH2:26][CH2:25]4)[CH2:19][CH2:18]3)[CH2:12][CH2:11]2)=[O:9])=[CH:6][C:5]=1[C:54]1[CH:59]=[C:58]([O:60][CH3:61])[C:57]([O:62][CH3:63])=[C:56]([O:64][CH3:65])[CH:55]=1>C(O)C>[ClH:1].[ClH:1].[CH3:38][O:37][C:34]1[CH:35]=[CH:36][C:31]([C:30]([N:27]2[CH2:26][CH2:25][CH:24]([CH2:23][N:20]3[CH2:19][CH2:18][N:17]([CH2:16][CH:13]4[CH2:14][CH2:15][N:10]([C:8](=[O:9])[C:7]5[CH:52]=[CH:53][C:4]([O:3][CH3:2])=[C:5]([C:54]6[CH:59]=[C:58]([O:60][CH3:61])[C:57]([O:62][CH3:63])=[C:56]([O:64][CH3:65])[CH:55]=6)[CH:6]=5)[CH2:11][CH2:12]4)[CH2:22][CH2:21]3)[CH2:29][CH2:28]2)=[O:51])=[CH:32][C:33]=1[C:39]1[CH:44]=[C:43]([O:45][CH3:46])[C:42]([O:47][CH3:48])=[C:41]([O:49][CH3:50])[CH:40]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770403HCID 18770403, compound

Product 1

HCID 18770402HCID 18770402, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.040 ml; 0.48 mmol) was added to a solution of 1,4-bis[[1-[4-methoxy-3-(3,4,5-trimethoxyphenyl)benzoyl]-4-piperidinyl]methyl]piperazine (80 mg; 0.090 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methanol-diethyl ether to obtain the title compound as colorless needles.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
  3. customthe resultant concentrated residue was recrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-bd53a9d707164148a49ca2c12ebd3e24
Source dataset
uspto-grants-2002_09
Patent number
US06448242B1

Reaction notes

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